1935
For the first time, Kontadi and Elko observed the presence of choline alfosophosphate (GPC) in their experiments.

1945
Schmidt, Hershman and Thannhausers succeeded in isolating relatively pure choline alfosinate (GPC) from bovine pancreas.

1948
Bear and Kates synthesized the active compound choline alfoscerate (GPC) for the first time.

1960
Studies have focused on the role of choline alfoscerate (GPC) in the nervous system.

1970
For the first time in Italy, choline alfoscerate (GPC) is used as a health supplement for brain function, including improved cognitive function and neuroprotection, and is gradually promoting the use of choline alfoscerate (GPC) worldwide.

1980
Exploration of clinical use: Investigators are beginning to explore the potential benefits of choline alfosciate (GPC) on cognitive function, particularly in Alzheimer's disease. Preliminary studies have shown that choline alfosalfosrole (GPC) may help improve memory and learning ability.

1990
Systematic studies: A number of clinical trials and studies have begun to systematically evaluate the effects of choline alfoscerate (GPC) on cognitive function. Some important findings in the 1990 s include that choline alfoscerate (GPC) can significantly improve cognitive function and activities of daily living in elderly patients. Italy was the first to market it as a drug.

2000
Major Breakthroughs:
Accumulation of clinical evidence: Multiple studies have confirmed the positive effects of choline alfoscerate (GPC) in patients with mild cognitive impairment and Alzheimer's disease, confirming its potential as a neuroprotective agent and cognitive enhancer.
Mechanism research:
Researchers began to explore the mechanism of action of choline alfoscerate (GPC), including how it affects acetylcholine synthesis and nerve cell protection.

2012
FDA Certification and International Recognition: Choline alfoscerate (GPC) is recognized in several countries, including in the United States by the FDA, for improving cognitive function. This phase also includes further studies on its efficacy and safety in different populations.
Application extension: The application was extended to athletes and healthy people to study its effects on enhancing athletic performance and improving attention. A variety of functional foods with choline alfoscerate (GPC) as raw materials have been listed.

2020
Further Certification: Choline alfoscerate (GPC) continues to be certified and recognized worldwide as a key ingredient in cognitive health supplements.

2022
Brand Group Jin Jiuqi
The exclusive patent preparation of phosphate choline (GPC) to declare the United States FDA GRAS certification.

2024
The brand's group Jin Jiuqi declared that the phosphate choline (GPC) was approved by China's National Health Commission for new food raw materials administrative license.

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